NIST SP 800-171 Rev 2 organizes 110 requirements into 14 families that drive CMMC Level 2 practice structure, and Microsoft 365 can shoulder a large share of the technical work in access, identity, logging, configuration, and data protection when paired with sound policy and scope control.
Sensitivity labels in Microsoft Purview set the digital markings and protections that keep CUI identifiable and controlled across Microsoft 365, and they integrate with DLP and audit to support NIST SP 800-171 and CMMC Level 2 practice implementation.
Continuous monitoring under NIST SP 800-171 means you operate, measure, and improve control performance with automation and human review on a defined cadence, then produce evidence that shows that operation over time.
Microsoft offers Microsoft 365 Copilot in GCC High within the sovereign tenant boundary, but feature gaps, web grounding choices, and CUI governance needs define where you can use it.